PENICILLIN V

PRODUCT IDENTIFICATION
CAS NO. 87-08-1

PENICILLIN V

EINECS NO. 201-722-0
FORMULA C16H18N2O5S
MOL WT. 350.39

H.S. CODE

 2941.10.2000

TOXICITY

  
SYNONYMS Phenoxymethylpenicillinic acid; PEN V; Phenopenicillin;
Phenoxymethylpenicillin; Fenoximetilpenicilina; Phénoxyméthylpenicilline; Penicillin phenoxymethyl; 6-Phenoxyacetamidopenicillanic acid;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 120 - 128 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH 2.5 - 4.0
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
· Penicillin: Any of a large group of broad-spectrum antibiotic drugs derived directly or indirectly from molds of the genus Penicillium and other soil-inhabiting fungi grown on special culture media, which exert a bacteriocidal as well as a bacteriostatic effect on susceptible bacteria during their growth stage by the inhibition of biosynthesis of their cell wall mucopeptide. Penicillin, beta-lactam antibiotics, possess a four-ring beta-lactam structure shares a nitrogen and a carbon atom with fused a five-membered thiazolidine ring. These antibiotics have low toxicity for the host but effective against most gram-positive bacteria including pathogens (streptococci, staphylococci, pneumococci); clostridia; some gram-negative gonococci; some spirochetes (Treponema pallidum and T. pertenue); and some fungi. Certain strains of some target species, e.g., staphylococci, secrete the enzyme penicillinase, which inactivates penicillin and confers resistance to the antibiotic.

· Penicillic acid [CAS RN: 90-65-3]: an antibiotic substance produced by several species of Penicillium and Aspergillus; a white solid soluble in water; melting point 83 - 84 C; antibiotic and mycotoxin induceing DNA single-strand breaks, toxic to animal tissues also, causing nephrotoxicity and other damage.

· Penicillin G [also called benzylpenicillin, CAS RN: 61-33-6]: the first and the most widely used penicillin compound for medicinal use. It is used in the form of its stable salts (benzathine, potassium, procaine, and sodium) to treat principally the infections due to penicillin-susceptible gram-positive bacteria, gram-negative cocci, Treponema pallidum, and Actinomyces israelii.

· Penicillin G Benzathine [CAS RN: 41372-02-5]: the benzathine salt of penicillin G; having a long-sustained action, administered orally, intramuscularly. Chemically designation is (2S,5R,6R)- 3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid with N,N' -Dibenzylethylenediamine (2:1). It is a white crystalline powder; slightly soluble in water and sparingly soluble in alcohol.

· Penicillin G Potassium [CAS RN: 113-98-4]: the potassium salt of penicillin G; administered orally and by intravenously. It is a white crystalline powder; odorless, moderately hygroscopic; soluble in water.

· Penicillin G Procaine [CAS RN: 6130-64-9]: the procaine salt of penicillin G; having a long-sustained action, administered intramuscularly. Chemically designation is (2S,5R,6R)- 3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid with 2-(Diethylamino)ethyl p-aminobenzoate (1:1). It is a white crystalline powder; slightly soluble in water.

· Penicillin G sodium [CAS RN: 69-57-8]: the sodium salt of penicillin G having a potency of 1500–1750 U per mg; administered intramuscularly and intravenously.

· Penicillin N (also called adicillin, CAS RN: 525-94-0]: a cephalosporin that is more active against gram-negative organisms than penicillin G and is highly active against Neisseria; has been used in the treatment of typhoid fever and gonorrhea.

· Penicillin O: similar to penicillin G in antibiotic action but produced by adding a precursor to the culture medium; penicillin O and its potassium and sodium salts are hypoallergenic.

· Penicillin V: [CAS RN: 87-08-1] a semisynthetic penicillin prepared from cultures of the mold Penicillium in the presence of 2-phenoxyethanol with an autolysate of yeast as the source of nitrogen; a white, crystalline powder, soluble in alcohol and acetone; resists destruction by high humidity (gastric juice), thus orally effective.

· Penicillin V Benzathine [CAS RN: 63690-57-3] : the benzathine salt of penicillin V, administered orally. Chemical designation is [2S-(2a,5a,6b)]-3,3 -dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4- thia-1- azabicyclo[3.2.0] heptane-2-carboxylic acid with N,N' -Dibenzylethylenediamine (2:1).

· Penicillin V Potassium [CAS RN: 132-98-9]: the potassium salt of penicillin V, administered orally. Chemical designation is [2S-(2a,5a,6b)]-3,3 -dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4- thia-1- azabicyclo[3.2.0] heptane-2-carboxylic acid, monopotassium salt.
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

pass

CONTENT (HPLC)

95.0 - 101.0%
POTENCY

1650 (units/mg)
OPTICAL ROTATION +186° ~ +199°

WATER (K.F)

0.5% max
COLOR

20max (4g/10 ml water; 425 nm)
ABSORBANCE 0.60 min (274 nm), 0.4 min (306 nm)
TRANSPORTATION
PACKING  
HAZARD CLASS Not regulated
UN NO.  
SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity, (Oral). Respiratory sensitization. Skin sensitization. Hazard statements: Harmful if swallowed. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled..

GHS

 

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H302-H317-H334

P STATEMENTS

P261-P280-P342+ P311

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

22-42/43

SAFETY PHRASES

22-26-36/37-45

PRICE INFORMATION